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Dr. Thon has published more than 30 peer-reviewed articles. Below are some of his most important publications.

Select Scientific Publications

  1. Thon, J.N., Devine, D.V. Translation of glycoprotein IIIa in stored platelets. Transfusion. 2007;47:2260-70.
  2. Thon, J.N.*, Schubert, P.*, Duguay, M., Serrano, K., Lin, S., Kast, J., Devine, D.V. Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches. Transfusion. 2008;48:425-35. *co-first authors
  3. Schubert, P., Thon, J.N., Walsh, G., Chen, C., Moore, E., Devine, D., Kast, J. A signaling pathway contributing to platelet storage lesion development: targeting PI3-kinase-dependent Rap1 activation slows storage-induced platelet deterioration. Transfusion. 2009;49:1944-55.
  4. Chase, T.H., Lyons, B.L., Bronson, R.T., Foreman, O., Donahue, L.R., Burzenski, L.M., Gott, B., Lane, P., Harris, B., Ceglarek, U., Thiery, J., Wittenburg, H., Thon, J.N., Italiano, J.E. Jr., Johnson, K.R., Shultz, L.D. The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010;115:1267-76.
  5. Thon, J.N., Montalvo, A., Patel-Hett, S., Devine, M.T., Richardson, J.L., Ehrlicher, A., Larson, M.K., Hoffmeister, K., Hartwig, J.H., Italiano, J.E. Jr. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010;191:861-74.
  6. Lu, S.J., Li, F., Yin, H., Feng, Q., Kimbrel, E.A., Hahm, E., Thon, J.N., Wang, W., Italiano, J.E., Cho, J., Lanza, R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011;21:530-45.
  7. Patel-Hett, S., Wang, H., Begonja, A., Thon, J.N., Alden, E., Wandersee, N., An, X., Mohandas, N., Hartwig, J., Italiano, J.E. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011;118:1641-52.
  8. Thon, J.N., Macleod, H., Begonja, A., Zhu, J., Lee, K., Mogilner, A., Hartwig, J., Italiano, J.E. Microtubule and cortical forces determine platelet size during vascular platelet production. Nature Communications. 2012;3:852.
  9. Thon, J.N., Peters, C.G., Machlus K.R., Aslam, R., Rowley, J., Macleod, H., Devine, M.T., Fuchs, T.A., Weyrich, A.S., Semple, J.W., Flaumenhaft, R., Italiano, J.E. T granules in human platelets function in TLR9 organization and signaling. Journal of Cell Biology. 2012;198:561-74.
  10. Thon, J.N., Devine, M.T., Begonja, A., Tibbits, J., Italiano, J.E. High-content live cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production. Blood. 2012;120:1975-84.

Peer-Reviewed Publications

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Other Peer-Reviewed Publications

  1. Thon, J.N.*, Schubert, P.*, Devine, D.V. Platelet storage lesion: A new understanding from a proteomic perspective. Transfus Med Rev. 2008;22:268-79. *co-first authors
  2. Thon, J.N., Italiano, J.E. Platelet formation. Semin Hematol. 2010;47:220-26.
  3. Thon, J.N., Italiano, J.E. Visualization and manipulation of the platelet and megakaryocyte cytoskeleton (Postdoctoral work). Meth Mol Biol. 2012;788:109-25.
  4. Thon, J.N., Italiano, J.E. Does size matter in platelet production? Blood. 2012;120:1552-61.
  5. Thon, J.N., Italiano, J.E. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol. 2012;210:3-22.
  6. Thon, J.N., Kitterman, A.C., Italiano, J.E. Animating platelet productions adds physiological context. Trends Mol Med. 2013;19:583-5. Corresponding author.
  7. Machlus, K.R., Thon, J.N., Italiano, J.E. Jr. Interpreting the developmental dance of the megakaryocyte. Brit J Haematol. 2014;165:227-36.